Figure 1
From: Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma
Differential gene expression between PNI cohorts. (A–C) Volcano plots showing each gene’s − log10 (p-value) and log2 fold change of (A) EXT-PNI versus Non-PNI, (B) EXT-PNI versus Focal-PNI, and (C) Focal-PNI versus Non-PNI cohorts. Genes that fall at the top and to either side of the plot are the most significantly DEGs. Dashed colored horizontal lines indicate adjusted p-value thresholds as shown. Solid colored horizontal lines indicate unadjusted p-value thresholds as shown. Dashed coloured vertical lines indicate fold change of ± 1.5 or 2 × (FC = 1.5 and FC = 2.0). The most statistically significant genes are labeled. (D,E) Venn diagrams showing DEG with (D) ≥ 3 or (E) ≤ − 3-fold change between cohorts as shown and adjusted p-values of < 0.01. The number of DEG for each pairwise comparison is indicated in the circles. Blue circles; DEG between EXT vs. Focal-PNI. Orange circles; DEG between EXT vs. Non-PNI. The overlap between the circles (purple) shows shared DEG genes between comparisons. (F) Significant up and down DEGs unique to EXT-PNI versus Focal-PNI comparison.
