Figure 1

Comparison of T2-weighted images of the prostate obtained at baseline pre-biopsy (a–c) and follow-up (d–f) mpMRI scans from patients enrolled on active surveillance. Images (a,d) were obtained from a patient with stable 3 + 3 = 6 disease that showed neither radiological not histopathological progression over a follow-up period of three years. Images (b,e) were obtained from a patient with both radiological (PRECISE 4) and histopathological (3 + 4 = 7 to 4 + 3 = 7) progression. Images (c,f) were obtained from a patient with confirmed histopathological progression (3 + 3 = 6 to 3 + 4 = 7) but radiologically stable disease (PRECISE 3). The best-performing predictive model (T2WI-derived radiomic features, PSA and PSA density) predicted the clinical outcome in all three presented cases.