Figure 1
From: Enrichment of low abundance DNA/RNA by oligonucleotide-clicked iron oxide nanoparticles
Description of InBeads capture system. (a) DNA-conjugated IONPs are incubated with a target solution to promote hybridization. Non-specifically hybridized DNA/RNA are removed by washes. Specifically hybridized DNA/RNA are retained on the magnetically immobilized beads. (b) Preparation of InBeads. (i) IONPs synthesis, (ii) silica coating, (iii) azide functionalization, and (iv) conjugation with DNA probes through click chemistry.
