Figure 1
From: Plasma lipidomic analysis shows a disease progression signature in mdx mice
Study overview. (A) Graph showing the study duration and age at sampling for WT, mdx and mdx mice with 2, 1 and no functional utrophin alleles. Samples were obtained at 6, 12, 18, 24 and 30 weeks of age. (B) Pie chart showing the lipid subclasses identified in mice plasma according to ChEBI names. We included in this chart subclasses that had more than 6 lipids in the dataset to improve readability. (C) Scatter plot showing the first 2 principal components for all analyzed samples. Colors indicate mice with different genotypes. WT mice (black) cluster at top left corner, while double knock out mice (green) are located at the bottom of the graph. The other 3 genotypes show large overlap. (D) Heatmap showing the hierarchical clustering of the correlation matrix for all lipids. Blocks with moderate correlations are visible. (E) Scatter plot showing for each detected lipid (x-axis) the number correlated lipids (Pearson absolute R value > 0.8).
