Table 1 Serum LDH activities (U/L) in 48 different types of clinical defined human diseases and healthy controls.
From: Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases
LDH | # of cases | Mean (SD) | Median (IQR) | p Value |
|---|---|---|---|---|
Acute myocardial infarction | 2639 | 331.9 (208.5) | 255.0 (184.0, 411.5) | < 0.001 |
Hepatic encephalopathy | 91 | 252.8 (93.8) | 232.0 (191.0, 297.5) | < 0.001 |
Preeclampsia | 992 | 237.0 (88.2) | 216.0 (174.0, 276.0) | < 0.001 |
Lung fibrosis | 336 | 236.3 (93.3) | 209.0 (172.0, 270.0) | < 0.001 |
Liver cancer | 299 | 219.7 (67.9) | 206.0 (167.0, 257.0) | < 0.001 |
Myeloproliferative disorder | 1294 | 243.2 (134.1) | 206.0 (163.0, 273.8) | < 0.001 |
Lupus erythematosus | 1333 | 216.4 (65.1) | 201.0 (168.0, 249.0) | < 0.001 |
Nephrotic syndrome | 3822 | 214.7 (64.4) | 201.0 (165.0, 248.8) | < 0.001 |
Aplastic anemia | 887 | 203.9 (60.0) | 195.0 (164.0, 239.5) | < 0.001 |
Rheumatic arthritis | 486 | 200.6 (51.8) | 192.5 (162.0, 227.8) | < 0.001 |
Diabetic nephropathy | 605 | 200.7 (48.8) | 192.0 (163.0, 233.0) | < 0.001 |
Brain trauma | 659 | 223.8 (120.9) | 192.0 (142.0, 255.0) | < 0.001 |
Anemia | 2063 | 221.4 (119.5) | 190.0 (152.5, 245.0) | < 0.001 |
Uremia | 6547 | 195.7 (52.0) | 186.0 (158.0, 223.0) | < 0.001 |
Lymphoma | 4811 | 209.8 (86.6) | 185.0 (155.0, 234.0) | < 0.001 |
Cirrhosis | 9328 | 198.7 (64.1) | 185.0 (153.0, 230.0) | < 0.001 |
Sepsis | 109 | 232.0 (121.8) | 184.0 (144.0, 290.0) | < 0.001 |
Psoriasis | 146 | 188.0 (45.3) | 183.0 (155.0, 214.8) | < 0.001 |
Azotemia | 497 | 192.7 (55.0) | 180.0 (151.0, 221.0) | < 0.001 |
Lung cancer | 10,943 | 188.7 (51.9) | 178.0 (152.0, 212.0) | < 0.001 |
Leukemia | 5416 | 224.3 (140.9) | 176.0 (140.0, 247.0) | < 0.001 |
Breast cancer | 5509 | 181.0 (36.4) | 175.0 (154.0, 202.0) | < 0.001 |
Ovarian cancer | 2357 | 184.3 (45.4) | 175.0 (153.0, 205.0) | < 0.001 |
Intracranial hemorrhage | 3839 | 192.6 (69.8) | 173.0 (142.0, 225.0) | < 0.001 |
Hepatitis | 6832 | 178.8 (41.1) | 171.0 (148.0, 200.0) | < 0.001 |
Chronic obstructive PD | 1651 | 186.6 (59.1) | 171.0 (145.0, 210.0) | < 0.001 |
Bone fracture | 1783 | 184.3 (54.9) | 171.0 (144.0, 209.0) | < 0.001 |
Encephalitis | 554 | 188.4 (70.4) | 171.0 (141.0, 216.0) | < 0.001 |
Endometrial cancer | 1217 | 175.7 (36.5) | 170.0 (149.0, 194.0) | < 0.001 |
Kidney cancer | 1553 | 180.9 (47.3) | 170.0 (147.0, 204.0) | < 0.001 |
Pancreatitis | 1835 | 209.5 (109.3) | 170.0 (138.0, 240.0) | < 0.001 |
Nephritis | 2156 | 180.7 (52.0) | 168.0 (142.0, 205.0) | < 0.001 |
Healthy controls > 65 years old | 811 | 167.8 (25.4) | 167.0 (149.5, 187.0) | – |
Coronary heart disease | 22,077 | 182.3 (59.8) | 167.0 (142.0, 204.0) | < 0.001 |
Multiple myeloma | 2330 | 181.4 (65.4) | 167.0 (139.0, 204.0) | < 0.001 |
Ankylosing spondylitis | 103 | 185.0 (60.2) | 165.0 (143.0, 218.0) | < 0.001 |
Cerebral arteriosclerosis | 821 | 171.9 (39.2) | 164.0 (144.0, 192.0) | < 0.001 |
Gastritis | 3401 | 169.8 (35.4) | 164.0 (144.0, 189.0) | < 0.001 |
Asthma | 602 | 178.6 (56.3) | 163.0 (143.0, 195.8) | < 0.001 |
Colon cancer | 6644 | 173.6 (49.9) | 163.0 (139.0, 197.0) | < 0.001 |
Pancreatic cancer | 1150 | 173.9 (50.1) | 163.0 (138.0, 200.0) | < 0.001 |
Gastric cancer | 13,497 | 167.7 (40.0) | 161.0 (139.0, 189.0) | < 0.001 |
Cervical cancer | 2276 | 161.9 (31.1) | 158.0 (139.0, 180.3) | < 0.001 |
Type 2 diabetes mellitus | 11,548 | 165.4 (38.4) | 158.0 (137.0, 186.0) | < 0.001 |
Rectum cancer | 8498 | 166.7 (42.3) | 158.0 (136.0, 188.0) | < 0.001 |
Esophagus cancer | 4025 | 165.6 (42.5) | 157.0 (135.0, 187.0) | < 0.001 |
Acute cerebral infarction | 9624 | 166.9 (47.3) | 156.0 (134.0, 186.0) | < 0.001 |
Healthy controls | 9528 | 156.2 (25.3) | 153.0 (137.0, 173.0) | – |
Cerebral ischemia | 2276 | 155.6 (32.7) | 150.0 (132.0, 173.0) | < 0.001 |
Gout | 1472 | 149.3 (32.3) | 144.0 (125.0, 168.0) | < 0.001 |
