Figure 3
From: Establishment and characterization of a new human colon cancer cell line, PUMC-CRC1
In vivo size assessment and histological analysis of the xenograft tumors in SCID mice. (a) Subcutaneous tumor mass (arrow indicated) in SCID mice which inoculated with 6 × 106 PUMC-CRC1 cells at 3 months post-injection. (b) Growth curve of the xenograft tumors in female and male SCID mice (n = 5, age 5–6 weeks), which started to increase in size at around 9 weeks after inoculation. (c) Xenografts derived from PUMC-CRC1 cells. (d–f) H&E staining of the paraffin-embedded tissue section confirmed that the xenograft tumor was moderately to poorly differentiated colorectal adenocarcinoma: (d) whole slide image of the xenograft tumor under low magnification; (e) irregular glandular cavity formation and cribriform structure; (f) cribriform structure and “dirty necrosis” within the glandular lumina.
