Table 3 Comparison of MSI status and mutation status of cancer critical genes in PUMC-CRC1 and 19 commonly-used CRC cell lines.
From: Establishment and characterization of a new human colon cancer cell line, PUMC-CRC1
Cell line | MSI status | APC | K-RAS | BRAF | PIK3CA | PTEN | TP53 | SMAD4 | MLH1 | PMS2 | MSH2 | MSH6 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
PUMC-CRC1 | MSS | p.T1493fs | p.G12V | wt | wt | wt | wt | p.V506A | wt | wt | wt | wt |
Caco-2 | MSS | p.Q1367* | wt | wt | wt | wt | p.C135F; p.E204* | p.D351H | wt | wt | wt | wt |
Colo201 | MSS | p.E1554fs | wt | p.V600E | wt | wt | wt | wt | wt | p.E504Q | wt | wt |
Colo205 | MSS | p.E1554fs | wt | p.V600E | wt | wt | wt | wt | wt | p.E504Q | wt | wt |
Colo320 | MSS | p.S811* | wt | wt | wt | wt | p.R248W | wt | wt | wt | wt | wt |
Colo678 | MSS | p.E1554fs | p.G12D | wt | wt | wt | wt | wt | wt | wt | wt | wt |
DIFI | MSS | p.E1151*; p.E443fs | wt | wt | wt | wt | p.K132R | wt | wt | wt | wt | wt |
HT-29 | MSS | p.E1554fs | wt | p.V600E | p.P449T | wt | p.V600E | p.Q311* | wt | wt | wt | wt |
NCI-H508 | MSS | wt | wt | p.G596R | p.E545K | wt | p.R273H | wt | wt | wt | wt | wt |
SW1116 | MSS | p.QTMP1429fs; p.Q264* | p.G12A | wt | wt | wt | p.A159D | wt | wt | p.D414fs | wt | wt |
SW480 | MSS | p.Q1338* | p.G12V | wt | wt | wt | p.R273H; p.P309S | wt | wt | wt | wt | wt |
SW620 | MSS | p.Q1338* | p.G12V | wt | wt | wt | p.R273H; p.P309S | wt | wt | wt | wt | wt |
T84 | MSS | p.L1489fs | p.G13D | wt | p.E542K | wt | p.? | p.K340N | wt | wt | wt | wt |
CW-2 | MSI-H | p.K1462fs; p.A528V; p.E2737G; p.I2756V; p.G470R; p.R302* | p.P140H | wt | p.P283S | p.P38H | p.P47P | wt | p.V152M; p.Y130fs | wt | wt | wt |
HCT116 | MSI-H | wt | p.G13D | wt | p.H1047R | wt | wt | wt | p.S252* | wt | wt | p.T1085fs |
HCT-15 | MSI-H | p.R727M; p.K993N; p.K1561N; p.I1779M; p.R2166*; p.E2550Q | p.G13D | wt | p.E545K; p.D549N | wt | p.S241F | wt | p.A120S; p.L348L | p.D543D | wt | p.T1189I; p.G289fs; p.DR1171fs; p.D1171fs; p.R1172del |
HRT-18 | MSI | p.R727M; p.K993N; p.R2166*; p.G1416fs | p.G13D; p.P110H | WT | p.E545K; p.D549N | p.Q87P; p.P96S | WT | p.D165E | p.A120S | wt | p.A600V | p.G289fs |
LOVO | MSI-H | p.R1114*; p.R2816Q p.T1430fs | p.G13D | wt | wt | wt | wt | wt | wt | wt | wt | wt |
LS180 | MSI-H | p.R1788C; p.K2193K | p.G12D | p.D211G | p.H1047R | p.I67K | wt | wt | p.T117M | wt | wt | p.T1085fs |
RKO | MSI-H | wt | wt | p.V600E | p.H1047R | wt | wt | wt | p.L323M | wt | wt | p.Y1066fs |
