Table 4 Univariate and multivariate analyses of factors associated with early extrahepatic recurrence.
Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
HR (95% CI) | p-value | HR (95% CI) | p-value | |
Serum ALP > 120 U/L | 2.790 (1.279–6.084) | 0.010 | 2.362 (1.018–5.478) | 0.045 |
Pathologic mUICC stage (III, IVa) | 3.418 (1.634–7.151) | 0.001 | 2.610 (1.154–5.901) | 0.021 |
Worst Edmonson Steiner grade ≥ 4 | 2.221 (1.063–4.643) | 0.034 | ||
Surgical margin involvement | 2.991 (1.043–8.576) | 0.041 | 4.035 (1.280–12.725) | 0.017 |
Venous/lymphatic involvement | 1.890 (0.925–3.860) | 0.081 | ||
Absence of fatty change | 3.582 (1.249–10.276) | 0.018 | 3.246 (1.114–9.461) | 0.031 |
Sum of tumor size > 7 cm | 2.142 (1.055–4.347) | 0.035 | ||
Macrovascular invasion | 3.818 (1.559–9.351) | 0.003 | 3.207 (1.169–8.799) | 0.024 |
