Table 2 Reaction condition optimization for RCM for compounds 28A and 28B.

From: Stereoselective synthesis of a 4-⍺-glucoside of valienamine and its X-ray structure in complex with Streptomyces coelicolor GlgE1-V279S

Catalyst (10 mol%)

Temperature

Solvent

Yield

Grubbs’ 2nd gen

rt

DCM

NR

Grubbs’ 2nd gen

40 °C

DCM

NR

Hoveyda Grubbs’

rt

DCM

NR

Grubbs’ 1st gen

rt

DCM

10–15%

Grubbs’ 1st gen

40 °C

DCM

25%

Grubbs’ 1st gen

rt

Toluene

14%

Grubbs’ 1st gen

80 °C

Toluene

15%

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