Figure 4 | Scientific Reports

Figure 4

From: Characterization of brain-wide somatosensory BOLD fMRI in mice under dexmedetomidine/isoflurane and ketamine/xylazine

Figure 4

Group response map and sensitivity under D/I and K/X anesthesia (ab) Group activation map after averaging all eight hours of runs under D/I (a) and K/X (b), cluster-wise FWE corrected P = 0.05. Labels in (a) point to clusters that appear under D/I, but not under K/X. OFC, orbital frontal cortex; RSC, retrosplenial cortex; ZI, zona incerta; S, subiculum; PAG, periaqueductal gray; CB, cerebellum. (c) Binarized response maps from (a) and (b) were summed to find commonly and exclusively significant clusters under both anesthesia. Coordinates below refer to distance from bregma in mm. (d) Group t-values extracted from anatomical ROIs based on the common and exclusive clusters from (c). Letter r in parenthesis means the right hemisphere responding to contralateral forepaw and ipsilateral whisker-pad stimulation. Data are mean ± SEM. Corrected two-sample t-test, *P < 0.05, **P < 0.01, ***P < 0.001.

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