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Figure 3

From: Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis

Figure 3

Effects of acitretin treatment or NB-UVB irradiation on HaCaT cells. Groups A–F: control, 1 µM acitretin, 50 mJ/cm2 NB-UVB, 1 µM acitretin + 50 mJ/cm2 NB-UVB, 100 mJ/cm2 NB-UVB, and 1 µM acitretin + 100 mJ/cm2 NB-UVB, respectively. (A) Analysis of HaCaT cell proliferation rate after indicated treatments. (B) Analysis of MMP13 mRNA levels in HaCaT cells treated as in (A). (C) Western blot analysis of MMP13 protein levels in HaCaT cells after indicated treatments. (D) Elisa analysis of MMP13 concentration in the supernatant of HaCaT cell. Data represent the mean ± standard deviation. \(^{*}P\) < 0.05, \(^{**}P\) < 0.01, \(^{***}P\) < 0.001 relative to control group. The data were analyzed with one-way ANOVA with Dunnett’s multiple test.

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