Table 1 Summary of identifying pathway regulators using triple-gene mutual interaction (TGMI) and sparse partial least squares (SPLS) in the top 50 transcription factors that have the highest connectivity to pathway genes.

From: Identification of biological pathway and process regulators using sparse partial least squares and triple-gene mutual interaction

Species

Tissues

Pathway

Number of positive TFs

Runtime TGMI/SPLS

TGMI

SPLS

In common

Arabidopsis

Stem

Flavanone, flavonol, anthocyannin

12

4

1

2.24/16.3 h

Arabidopsis

Stem

Lignin

23

20

13

0.64/20.09 h

Populus

Xylem

Lignin

22

7

7

0.85/7.14 h

Arabidopsis

Leaf

Photosynthesis (Light reaction + Calvin cycle)

16

8

4

12.91/70.24 h

Arabidopsis

Leaf

Light reaction

14

7

6

–/–

  1. *These computing times were measured on Unix Intel(R) Xeon(R) CPU X5460 @ 3.16 GHz, with 2 physical ID, 4 cpu cores, 8 processors.