Table 1 Characteristics of the study population stratified by hepatic steatosis (MRI).
Variables | Number of individuals | Hepatic steatosis derived from MRI | P value | |
|---|---|---|---|---|
No (n = 1,106) | Yes (n = 640) | |||
Age (years) | 1746 | 46 (37; 57) | 55 (47, 64) | < 0.001 |
Male | 833 | 459 (42%) | 374 (58%) | < 0.001 |
Female | 913 | 647 (58%) | 266 (42%) | < 0.001 |
BMI (kg/m2) | 1746 | 25 (23; 28) | 30 (27; 32) | < 0.001 |
Alcohol consumption (g/day) | 1732 | 4 (1; 9) | 5 (1; 14) | < 0.001 |
Hepatic steatosis ultrasound | < 0.001 | |||
Negative | 1119 | 949 (86%) | 170 (27%) | |
Positive | 619 | 152 (14%) | 467 (73%) | |
Liver fat (MRI %) | 1746 | 2.6 (2; 3.5) | 9.4 (6.7; 15.2) | < 0.001 |
ALT (µkatal/l) | 1745 | 0.33 (0.25; 0.43) | 0.49 (0.36; 0.67) | < 0.001 |
AST (µkatal/l) | 1743 | 0.27 (0.21; 0.33) | 0.32 (0.26; 0.40) | < 0.001 |
GGT (µkatal/l) | 1745 | 0.43 (0.35; 0.56) | 0.64 (0.48; 0.93) | < 0.001 |
HbA1c % | 1745 | 5.1 (4.8; 5.4) | 5.3 (5; 5.6) | < 0.001 |
Glucose (mmol/l) | ||||
Fasting | 1746 | 5.2 (4.9; 5.6) | 5.7 (5.3; 6.1) | < 0.001 |
2-h | 1622 | 5.6 (4.8; 6.6) | 6.6 (5.6; 8.1) | < 0.001 |
Insulin (µU/ml) | ||||
Fasting | 1617 | 7.5 (5.5; 10.5) | 13.8 (9.6; 20.1) | < 0.001 |
2-h | 1619 | 39 (25; 58) | 72 (47; 145) | < 0.001 |
HOMA-IR | 1617 | 1.8 (1.2; 2.5) | 3.5 (2.3; 5.3) | < 0.001 |
OGTT | < 0.001 | |||
NGT | 918 | 710 (69%) | 208 (35%) | |
i-IFG | 404 | 208 (20%) | 196 (33%) | |
i-IGT | 87 | 39 (4%) | 48 (8%) | |
IFG + IGT | 133 | 49 (5%) | 84 (14%) | |
Undiagnosed T2DM | 80 | 17 (2%) | 63 (10%) | |
