Table 2 Relative amount of proteins secreted by Clostridioides difficile strains ICC-45 and NAP1/027 (LIBA5756).

From: Exoproteomic analysis of two MLST clade 2 strains of Clostridioides difficile from Latin America reveal close similarities

Identified proteins	Access number (gi)	Gene name^a	MW (kDa)^a	Total Spectrum^b (ICC-45)	Total Spectrum^b (NAP1)
Proteins involved in pathogenicity
Cell surface protein (S-layer precursor protein)	gi\|255307831	slpA	76	5359	4001
Toxin A	gi\|255305655	tcdA	308	3399	2202
Toxin B	gi\|126698238	tcdB	269	2633	1501
Cell surface protein	gi\|1001999562	cwp19	77	45	37
Cell wall protein	gi\|400927472	cwp22	71	18	4
Cell-wall hydrolase	gi\|126700384	CD630_2768	25	30	11
Cell wall binding repeat 2 family protein	gi\|531118578	cwp28	51	13	2
Flagellin subunit	gi\|260685615	fliC	34	38	0
Cell surface protein (putative cell surface-associated cysteine protease)	gi\|260210525	cwp84	87	62	14
Proteins involved in antimicrobial resistance
Beta-lactamase family protein	gi\|531115368	QEW_1874	112	49	14
Pyruvate-ferredoxin oxidoreductase	gi\|126700296	Pfo	128	895	650
Nitroreductase	gi\|126700191	CD630_2572	24	12	8
Proteins related to oxidative stress and thermal shock
Rubrerythrin	gi\|126699128	CD630_15240	20	515	573
Cysteine desulfurase	gi\|126698876	iscS2	43	115	52
Chaperone DnaK	gi\|126700078	dnaK	66	527	335
60 kDa chaperonin	gi\|255305190	groL	57	312	167
Heat shock protein 90	gi\|126697845	htpG	75	19	3
Proteins involved in resistance to nitric oxide
Anaerobic nitric oxide reductase flavorubredoxin	gi\|126698752	norV	44	171	58
Putative nitric oxide reductase flavoprotein	gi\|255306635	CDR20291_1521	94	87	84
Proteins involved with metabolism and catalytic activity
Trehalose-6-phosphate hydrolase	gi\|126700708	treA	66	266	156
Phosphoenolpyruvate-protein phosphotransferase	gi\|260687988	ptsI	63	114	75
Chain D, Alanine Racemase	gi\|645985739	alr2	43	43	9
Proteins involved in other activities
d-Proline reductase PrdA	gi\|126700863	prdA	67	39	22
Transcription elongation factor GreA	gi\|126701179	greA	18	21	1
Cold shock protein CspB	gi\|126698954	cspB	7	663	670
Pilin	gi\|255308544	CD630_3513	18	32	26

^aFunctional annotations were taken from the Swiss protein database (https://www.uniprot.org).
^bConcentration based on the amount of total spectrum found using Scaffold (v. 4.8.6.0; Proteome Software Inc., Portland, Oregon, USA).

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Table 2 Relative amount of proteins secreted by Clostridioides difficile strains ICC-45 and NAP1/027 (LIBA5756).

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