Figure 2 | Scientific Reports

Figure 2

From: Plasmodium falciparum phenotypic and genotypic resistance profile during the emergence of Piperaquine resistance in Northeastern Thailand

Figure 2

In vitro characterization. (A) RSA and pfk13 mutations. RSA0-3 h survival rate for standard laboratory-adapted clones (W2 for ART-sensitive control, IPC-4884 and IPC-5202 for ART-resistance control) and culture-adapted clinical isolates. The dashed line represents the 1% survival rate cut-off that differentiates ART-resistance (≥ 1% red-dashed line) from ART-sensitive (< 1%) parasites in RSAs. Median and interquartile ranges are shown. (B) IC90 to PIP in parasites with pfcrt-F145I mutation, with and without pfpm2 amplification. Copy number variations of pfpm2 are shown on the x-axis, and PIP-IC90 is shown on the y-axis (log10 scale).

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