Figure 4 | Scientific Reports

Figure 4

From: Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2-specific IgA in patients with acute COVID-19

Figure 4

Gut microbiome and fecal SARS-CoV-2 genome sequencing of COVID-19 patients. (A) PCoA (Bray–Curtis dissimilarity) of 16S rRNA gene amplicon and shotgun metagenomic sequencing of fecal samples from donors stratified by COVID-19 severity. (B) Alpha diversity (Shannon entropy) is not significantly altered in mild, moderate or severe COVID-19. (C) PCoA (Bray–Curtis dissimilarity) of 16S rRNA gene amplicon and shotgun metagenomic sequencing of fecal samples from donors with and without diarrhea. (D) Gut microbiome alpha diversity (Shannon entropy) in patients with and without diarrhea and as relates to the Bristol score of each sample. (E) PCoA (Bray–Curtis dissimilarity) of 16S rRNA gene amplicon and shotgun metagenomic sequencing of fecal samples from patients receiving or not receiving antibiotic therapy. (F). Gut microbiome alpha diversity (Shannon entropy) is reduced in hospitalized COVID-19 patients recently or currently receiving antibiotic therapy (Abx). Boxplots show median + / − IQR.

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