Table 1 Tumourigenicity and metastatic potential of the P29 cybrids used in this study.
Cybrid | mtDNA | Tumourigenicity | No. of pulmonary metastasis | ||
|---|---|---|---|---|---|
Tumour take/No. of mice tested | No. of mice with metastatic foci / No. of mice tested | Median (Range) | P value* (vs P29mtP29) | ||
ρ0P29 | None | 0/6 | nd | – | |
P29mtP29 | Wild-type | 8/8 | 3/6 | 0.5 (0–4) | |
P29mtΔ | 4696 bp deletion | 0/6 | nd | – | |
P29mtCOIM | COI G13997A | 13/14 | 1/7 | 0 (0–1) | ns |
P29mtA11 | ND6 G13997A | 8/8 | 7/7 | 2 (1–9) | 0.0329 |
P29mtB82M | ND6 13891insC | 8/8 | 7/7 | 38 (16–87) | 0.0059 |
