Table 2 Uni- and multivariate Cox regression models for OS.
From: The prognostic relevance of HER2-positivity gain in metastatic breast cancer in the ChangeHER trial
Univariate Cox regression model | Multivariate Cox regression modela | ||||
|---|---|---|---|---|---|
HR (95%CI) | p-value | HR (95%CI) | p-value | ||
Age | > 65 years vs ≤ 65 years | 1.03 (0.56–1.91) | 0.91 | ||
IHC subtype | TP vs ER or PgR + vs other | – | 0.92 | ||
ER or PgR + vs TP | 0.99 (0.65–1.51) | 0.97 | |||
Other vs TP | 1.07 (0.75–1.51) | 0.72 | |||
ER | Negative vs Positive | 1.07 (0.77–1.48) | 0.69 | – | – |
PgR | Negative vs Positive | 1.04 (0.76–1.42) | 0.80 | – | – |
Visceral metastases | Yes vs No | 1.11 (0.79–1.58) | 0.54 | – | – |
DFS | < 3 years vs ≥ 3 years | 1.69 (1.23–2.32) | 0.001 | 1.69 (1.23–2.32) | 0.001 |
HER2 + at baseline | Yes vs No | 1.51 (0.96–2.38) | 0.072 | – | – |
Brain metastases | Yes vs No | 2.09 (1.51–2.89) | < 0.0001 | 1.98 (1.43–2.75) | < 0.0001 |
