Figure 1
From: The effect of protein mutations on drug binding suggests ensuing personalised drug selection
Chemical structures of the 6 ligands that have been investigated (a), and positions of the mutations identified from 50 breast cancer patients of Qatari nationals, in both the active (b) and inactive (c) conformations. The PDB code of the active conformation crystal structure is 1QKU, and the inactive conformation is 3ERT. The ligands presented in the crystal structures are represented as stick in orange, the protein is shown as cartoon in silver. The helix 12 (H12) is highlighted in blue, which shows different orientations in the active (b) and inactive (c) conformations.
