Figure 2
From: The effect of protein mutations on drug binding suggests ensuing personalised drug selection
Conformational free energy changes of the active and inactive states due to mutation. The mutations change the relative energy differences between the two states, and hence shift the balance between them. The 2D energy surface illustrates an example of the energy changes at the two states, from wild-type (orange) to mutant (light blue), rendering the active state more favourable for the mutant protein than the wild-type. It should be noted that the 2D energy surface is an illustration as the free energy difference between the active and inactive conformations of the wild type, and the energy barrier between them (the dashed line) are unknown.
