Table 1 The numbers of cancer-related and neutral SAVs for each wild-type (WT) residue and the total (bolded) in our training and independent datasets.

WT	Training set				Independent set 30		Independent set 40
WT	Cancer	Neutral	Total	Ratio (δ)	Cancer	Neutral	Cancer	Neutral
ALA	187	657	844	0.2846	12	191	26	268
CYS	45	97	142	0.4639	6	21	9	36
ASP	216	412	628	0.5243	14	121	26	167
GLU	254	408	662	0.6225	11	114	27	174
PHE	85	127	212	0.6693	9	46	14	58
GLY	236	437	673	0.5400	11	129	21	171
HIS	77	188	265	0.4096	6	63	9	85
ILE	116	437	553	0.2654	5	113	9	178
LYS	98	263	361	0.3726	6	98	12	131
LEU	178	321	499	0.5545	6	99	17	141
MET	63	202	265	0.3119	2	56	12	83
ASN	90	340	430	0.2647	5	107	8	153
PRO	200	363	563	0.5510	9	100	24	134
GLN	83	212	295	0.3915	7	55	14	78
ARG	328	1,248	1,576	0.2628	14	335	30	459
SER	217	432	649	0.5023	12	131	25	176
THR	150	505	655	0.2970	7	146	13	203
VAL	156	695	851	0.2245	7	236	16	315
TRP	24	42	66	0.5714	1	14	3	22
TYR	64	176	240	0.3636	4	65	7	95
TOTAL	2,867	7,562	10,429	0.3791	154	2,240	322	3,127

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