Table 2 List of descriptors in the sequence-based feature set.

From: The structure-based cancer-related single amino acid variation prediction

#

Feature name

#

Feature name

1

Substitution index: BLOSUM62

23

AAC: H-hydrophobic (CVLIMFW)

2

Substitution index: PAM250

24

AAC: V-small (GASCTPD)

3

Substitution index: PSSM

25

AAC: V-medium (NVEQIL)

4

Entropy: 7th residue before SAV

26

AAC: V-large (MHKFRYW)

5

Entropy: 6th residue before SAV

27

AAC: Z-low polarizability (GASDT)

6

Entropy: 5th residue before SAV

28

AAC: Z-neutral (PATGS)

7

Entropy: 4th residue before SAV

29

AAC: Z-high polarizability (KMHFRYW)

8

Entropy: 3rd residue before SAV

30

AAC: P-low polarity (LIFWCMVY)

9

Entropy: 2nd residue before SAV

31

AAC: P-neutral polarity (PATGS)

10

Entropy: 1st residue before SAV

32

AAC: P-high polarity (HQRKNED)

11

Entropy: SAV

33

AAC: F-acidic (DE)

12

Entropy: 1st residue after SAV

34

AAC: F-basic (HKR)

13

Entropy: 2nd residue after SAV

35

AAC: F-polar (CGNQSTY)

14

Entropy: 3rd residue after SAV

36

AAC: F-nonpolar (AFILMPVW)

15

Entropy: 4th residue after SAV

37

AAC: E-acidic (DE)

16

Entropy: 5th residue after SAV

38

AAC: E-basic (HKR)

17

Entropy: 6th residue after SAV

39

AAC: E-aromatic (FWY)

18

Entropy: 7th residue after SAV

40

AAC: E-amide (NQ)

19

Entropy: Average of 15 residues

41

AAC: E-small hydroxyl (ST)

20

Entropy: Average of 5 residues

42

AAC: E-sulfur-containing (CM)

21

AAC: H-polar (RKEDQN)

43

AAC: E-aliphatic 1 (AGP)

22

AAC: H-neutral (GASTPHY)

44

AAC: E-aliphatic 2 (ILV)