Table 3 Grouped analysis of average NfL levels per diagnostic criteria, comparing no dementia and dementia.

From: The reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population

 

DSM-IV

ICD-10

Clinical Judgement

DSM-5

Median NfL ng/L (range)

Mean NfL ng/L (S.D.)

Median NfL ng/L (range)

Mean NfL ng/L (S.D.)

Median NfL ng/L (range)

Mean NfL ng/L (S.D.)

Median NfL ng/L (range)

Mean NfL ng/L (S.D.)

No Dementia or NCD

31.3 (10.6 –112.6)

37.6 (25.4)

30.2 (10.7–136.9)

37.6 (28.3)

27.5 (10.7–81.8)

32.2 (19.8)

24.9 (10.7–79.1)

29.7 (18.1)

Dementia or any NCD

50.3 (11.1–136.9)

58.4(40.7)

48.3 (11.1–111.1)

53.9 (32.9)

41.4 (11.1–136.9)

52.6 (35.5)*

41.4 (11.1–136.9)

53.1 (34.5)**

  1. *Between group significance p < 0.05.
  2. **Between group significance p < 0.01.