Table 4 Average NfL levels for individuals grouped according to DSM-5 criteria and for groups according to clinical judgement.

From: The reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population

 

N (%)

Mean age, years (SD)

Median NfL level ng/L (range)

Mean NfL ng/L (SD)

NCD diagnosis

No NCD

24 (44)

48.3 (6.5)

24.9 (10.7 -79.1)

29.7 (18.1)

Mild NCD

14 (26)

54.5 (7.0)

39.6 (15.2–112.6)

51.4 (30.6)

Major NCD

16 (30)

56.9 (10.3)

44.4 (11.1 – 136.9)

54.8 (38.5)

Clinical diagnosis

No Dementia

14 (26)

47.7 (6.8)

18.6 (10.7–79.1)

26.9 (20.8)

Cognitive Concern

12 (22)

51.8 (6.3)

32.5 (20.6 – 81.8)

38.3 (17.3)

Dementia

28 (52)

55.1 (9.5)

41.3 (11.1 – 136.9)

52.6 (35.5)