Table 1 Demographic and baseline clinical characteristics.

From: Early extubation with immediate non-invasive ventilation versus standard weaning in intubated patients for coronavirus disease 2019: a retrospective multicenter study

 

Standard weaning (n = 55)

Early extubation (n = 66)

P value

Characteristics

 Age, years

64.0 [58.0–69.0]

62.5 [54.8–70.3]

0.514

 Male, n (%)

49 (89.1)

48 (72.7)

0.038

 BMI, kg*m−2

27.8 [24.0–30.1]

26.6 [24.3–30.5]

0.650

 SAPS II

40.0 [30.0–46.0]

34.0 [29.0–42.0]

0.212

 SOFA

7.0 [3.5–8.0]

5.0 [3.0–8.0]

0.550

Comorbidities

 Chronic arterial hypertension, n (%)

36 (65.5)

23 (34.9)

0.001

 Ischaemic heart disease, n (%)

6 (10.9)

0 (0.0)

0.008

 Diabetes, n (%)

10 (18.2)

11 (16.7)

 > 0.999

 COPD, n (%)

7 (12.7)

2 (3.0)

0.077

 Kidney disease, n (%)

2 (3.6)

1 (1.5)

0.590

 Obesity (BMI ≥ 30 kg*m−2), n (%)

18 (32.7)

17 (25.8)

0.427

 Other medical disease, n (%)

33 (60.0)

27 (40.9)

0.045

 Active smoke, n (%)

22 (40.0)

8 (12.1)

 < 0.001

 Time lag between symptoms onset and hospital admission, days

6.4 (5.0–9.5)

7.0 (4.0–10.0)

0.918

 NIV duration before intubation, days

2.0 (1.0–3.0)

1.0 (0.0–2.3)

0.003

  1. Data are presented as number and percentage of patients (in brackets) or median and interquartile range [in brackets]. BMI, body mass index; SAPSII, simplified acute physiology score II, SOFA, sequential organ failure assessment; COPD, chronic obstructive pulmonary disease; NIV, non–invasive ventilation. P values refer to Fisher’s exact test or Mann–Whitney test.
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