Table 2 Effects of LP, NAC, and/or CP on antioxidant parameters in hepatic tissues (n = 7).

From: Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats

Parameters

Control

LP

NAC

CP

LYP + CP

NAC + CP

LP + NAC + CP

MDA (nmol/g)

141.81 ± 1.36e

144.88 ± 2.43e

143.5 ± 2.08e

283.37 ± 3.92a

187.84 ± 3.03c

201.16 ± 3.04b

172.87 ± 5.18d

CAT (U/g)

3.22 ± 0.04a

3.28 ± 0.04a

3.19 ± 0.04a

2.31 ± 0.06e

2.69 ± 0.03d

2.88 ± 0.06c

3.03 ± 0.04b

SOD (U/g)

33.32 ± 0.72a

32.86 ± 0.70a

34.03 ± 0.64a

21.01 ± 0.27d

24.64 ± 0.85c

25.02 ± 0.52c

29.88 ± 0.70b

GSH (mg/g)

122.96 ± 3.16a

119.46 ± 3.03a

121.05 ± 2.87a

81.48 ± 2.61d

92.31 ± 0.90c

93.05 ± 0.52c

106.65 ± 2.95b

  1. Data are expressed as the mean ± SE (n = 7). Different superscript letters in the same row indicate statistical significance at P ≤ 0.05.
  2. Cisplatin (CP) at a single dose of 7.5 mg/kg (IP); Lycopene (LP) at dose of 10 mg/kg; N-acetycysteine (NAC) at a dose of 150 mg/kg.
  3. Malondialdehyde (MDA); catalase (CAT); superoxide dismutase (SOD); reduced glutathione (GSH).