Table 3 Effects of LP, NAC, and/or CP on antioxidant parameters in renal tissues.

From: Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats

Parameters

Control

LP

NAC

CP

LYP + CP

NAC + CP

LP + NAC + CP

MDA (nmol/g)

73.49 ± 0.77d

70.76 ± 0.80d

71.28 ± 1.07d

143.07 ± 4.85a

117.31 ± 2.11b

122.95 ± 5.16b

94.68 ± 1.56c

CAT (U/g)

2.20 ± 0.04bc

2.30 ± 0.04ab

2.32 ± 0.02a

1.43 ± 0.03e

1.82 ± 0.02d

1.78 ± 0.03d

2.09 ± 0.03 c

SOD (U/g)

16.52 ± 0.19a

17.08 ± 0.43a

16.45 ± 0.26a

3.50 ± 0.15e

6.21 ± 0.06c

5.41 ± 0.11d

7.16 ± 0.23b

GSH (mg/g)

80.96 ± 1.76a

78.20 ± 0.45ab

81.12 ± 1.04a

45.58 ± 1.15e

53.62 ± 0.89d

64.15 ± 1.07c

75.65 ± 0.86b

  1. Data are expressed as the mean ± SE (n = 7). Different superscript letters in the same row indicate statistical significance at P ≤ 0.05.
  2. Cisplatin (CP) at a single dose of 7.5 mg/kg (IP);; Lycopene (LP) at dose of 10 mg/kg ;N-acetycysteine (NAC) at a dose of 150 mg/kg.
  3. Malondialdehyde (MDA); catalase (CAT); superoxide dismutase (SOD); reduced glutathione (GSH).