Table 5 Relationships between HMGB1 expression and clinicopathological parameters.

From: Tumor heterogeneity evaluated by computed tomography detects muscle-invasive upper tract urothelial carcinoma that is associated with inflammatory tumor microenvironment

 

HMGB1 IHC

p value

Weak

Strong (%)

Hydronephrosis

 Mild

41

18 (30.5%)

0.1169

 Severe

14

13 (48.2%)

Urine cytology

 Negative

28

12 (30.0%)

0.2746

 Positive

12

19 (41.3%)

T stage

 Ta-T1

42

7 (14.3%)

< 0.0001

 T2-T4

13

24 (64.9%)

Histological grade

 Low grade

26

3 (10.3%)

0.0002

 High grade

29

28 (49.1%)

Lymphovascular invasion

 Not evident

43

16 (27.1%)

0.0116

 Evident

12

15 (55.6%)

Concomitant CIS

 No

45

18 (28.6%)

0.0184

 Yes

10

13 (56.5%)

  1. HMGB1 high mobility group box 1, IHC immunohistochemistry, CIS carcinoma in situ.
  2. The significance of bold means p < 0.05.
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