Figure 2

Multimodal imaging of the left eye of a 38-year-old woman with chronic central serous chorioretinopathy and subsequent polypoidal choroidal vasculopathy. (A) Fluorescein angiography revealing focal leakage points (white arrows). (B) Multifocal hyperfluorescent areas (white arrows) shown on the indocyanine green angiography (ICGA) in the middle phase. Pachyvessels can be seen in the inferotemporal quadrant; they do not taper toward the posterior pole and terminate abruptly. (C–H) Polypoidal choroidal vasculopathy developed subsequently at the 10-year follow-up. (C) ICGA revealing a branching vascular network with terminal aneurysmal dilatations. (D) Optical coherence tomography angiography (OCTA) image, with segmentation from 19 to 49 μm with respect to the retinal pigment epithelium (RPE), demonstrating type 1 (sub-RPE) neovascularization overlaying the attenuated choriocapillaris (white arrowheads). (E) Focal inward displacement of the underlying pachyvessels (white arrowheads) on OCTA image, with segmentation from 24 to 44 μm with respect to Bruch’s membrane. (F) OCTA image, with segmentation from 64 μm to 125 μm with respect to Bruch’s membrane, revealing dilated choroidal vessels. (G) OCT image revealing an elevated RPE detachment and the presence of subretinal fluid. (H) OCT image showing resolution of subretinal fluid following two doses of monthly intravitreal injection of anti-VEGF.