Figure 1
From: Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
Weight changes, food consumption, core body temperature, and locomotor activity. The experiment timeline showing sleep and pain tests during predictable chronic mild stress (PCMS) (a). Significant weight decrease was seen in the water (W) group on days 9, 15, 18, and 21 of the PCMS timeline compared to the control (C) group (b). Food consumption increased for the W group on days 6, 9, 12, 15, 18, and 21 (c). No changes in terms of core body temperature were observed (d). There were no significant changes in locomotor activity as well (e). N = 6–7 per group; ¥p < 0.05, ¥¥p < 0.01, ¥¥¥p < 0.001 (W vs C); two-way repeated-measures ANOVA followed by Dunnett’s multiple comparison test. Data are presented as means ± SEM.
