Figure 4
From: Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
Comparison of RT-PCR results of cytokine expression. In terms of tumor necrosis factor alpha (TNF-α) expression, no significant changes were seen in the frontal cortex (FCX), thalamus, hippocampus, and dorsal root ganglion (DRG). However, significant increases in the hypothalamus were observed in the water (W) group and the trigeminal ganglion (TG) in the mesh wire (MW) compared to the control (C) group (a). Higher expressions of interleukin-6 (IL-6) were found in the thalamus of the W group only (b). Plasma corticosterone levels were higher across all predictable chronic mild stress (PCMS) groups than the control (c). N = 4–6 per group (RT-PCR); N = 8–11 per group (Corticosterone); *p < 0.05, ***p < 0.001; one-way ordinary ANOVA followed by Dunnett’s multiple comparison test. Data are presented as means ± SEM.
