Figure 1

Illustration of the 5′ area of the human CCL2 gene (UCSC Genome Browser, Human Feb. 2009 GRCh37/hg19 Assembly) with mapped potential CCL2 promoter variants used for deletion screening. The numbers indicate positions in response to the CCL2 transcription start site. H3K4Me1 the track indicating areas of monomethylation of Histone H3 at lysine 4, H3K4Me3 the track indicating areas of trimethylation of Histone H3 at lysine 4, H3K27Ac the track indicating areas of acetylation of Histone H3 at lysine 27, DNase I hypersensitivity the track indicating deoxyribonuclease I hypersensitivity clusters.