Figure 5 | Scientific Reports

Figure 5

From: Substrate reduction therapy for Krabbe disease and metachromatic leukodystrophy using a novel ceramide galactosyltransferase inhibitor

Figure 5

CGT inhibition improves histological and immunological markers in Twitcher mice. Brain sections from Twitcher (Twi) mice treated with 0.15 mg/kg S202 by IP injection three times per week from PND3 to PND28 were immunologically stained for CD68, GFAP and MBP (A,C,E) and quantified (B,D,F). Percent immunoreactivity represents the area of staining within the region analyzed (cerebellar white matter, 100%). Cytokine levels from brain homogenates harvested from the same mice were analyzed and MCP-1 and GROA were reduced upon S202 treatment (G,H). N = 3–4 (A–H).

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