Figure 6 | Scientific Reports

Figure 6

From: Substrate reduction therapy for Krabbe disease and metachromatic leukodystrophy using a novel ceramide galactosyltransferase inhibitor

Figure 6

Older Twitcher mice better tolerate S202 but higher doses are required to increase survival. Survival curves of Twitcher mice treated with S202 starting on PND15 (A) and median days of survival (B). Treating Twitcher mice starting from PND15 with S202 dose dependently reduced non-hydroxy-GalCer (C), 2-hydroxy-GalCer (D), and psychosine (E) (n = 3–4).

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