Table 2 Association of relative platelet reductions and platelet counts with in-hospital mortality for patients with sepsis.

From: Relative platelet reductions provide better pathophysiologic signatures of coagulopathies in sepsis

Cohort

Crude Odds ratio (95% CI)

Adjusted odds ratio (95% CI)a

P Value

Primary cohort

Relative platelet reduction (%)

 < 20

Reference

Reference

 

 20–40

1.69 (1.64–1.74)

1.28 (1.23–1.32)

 < 0.001

 40–60

2.98 (2.83–3.15)

1.86 (1.75–1.97)

 < 0.001

 60–80

5.47 (4.94–6.05)

2.99 (2.66–3.36)

 < 0.001

 ≥ 80

13.56 (10.29–17.98)

6.05 (4.40–8.31)

 < 0.001

 Absolute platelet count on day 2b

1.29 (1.27–1.30)

1.20 (1.18–1.21)

 < 0.001

Interaction with relative platelet reduction

 × thrombocytopeniac

 

1.08 (1.02–1.15)

0.006

 × shockd

 

0.81 (0.77–0.86)

 < 0.001

 × respiratory failuree

 

0.99 (0.94–1.05)

0.737

 × coagulopathy related complications

 

0.9 (0.75–1.1)

0.339

Patient without resultant thrombocytopeniac

Relative platelet reduction (%)

 < 20

Reference

Reference

 

 20–40

1.70 (1.64– 1.76)

1.30 (1.24–1.36)

 < 0.001

 40–60

2.48 (2.32– 2.65)

1.64 (1.48–1.82)

 < 0.001

 60–80

4.88 (4.26– 5.58)

3.10 (2.30–4.17)

 < 0.001

 ≥ 80

12.82 (8.95– 18.50)

0.52 (0.06–4.28)

0.55

 Absolute platelet count on day 2b

1.03 (0.99–1.06)

0.97 (0.94–1.00)

0.07

Patient with resultant thrombocytopeniac

Relative platelet reduction (%)

 < 20

Reference

Reference

 

 20–40

1.59 (1.48–1.70)

1.17 (1.10–1.25)

 < 0.001

 40–60

3.46 (3.16–3.79)

1.69 (1.56–1.83)

 < 0.001

 60–80

4.78 (4.08–5.59)

2.47 (2.15–2.83)

 < 0.001

 ≥ 80

16.46 (10.10–28.00)

6.55 (4.54–9.46)

 < 0.001

 Absolute platelet count on day 2b

1.59 (1.53–1.65)

1.38 (1.32–1.44)

 < 0.001

Patient with shockd

Relative platelet reduction (%)

 < 20

Reference

Reference

 

 20–40

1.32 (1.26–1.39)

1.13 (1.07–1.19)

 < 0.001

 40–60

2.13 (1.98–2.30)

1.59 (1.45–1.73)

 < 0.001

 60–80

3.30 (2.83–3.83)

2.26 (1.89–2.71)

 < 0.001

 ≥ 80

6.90 (4.83–9.91)

4.82 (3.16–7.34)

 < 0.001

 Absolute platelet count on day 2 b

1.22 (1.20–1.25)

1.14 (1.12–1.17)

 < 0.001

Patient with respiratory failuree

Relative platelet reduction (%)

 < 20

Reference

Reference

 

 20–40

1.63 (1.55–1.71)

1.18 (1.12–1.25)

 < 0.001

 40–60

2.46 (2.26–2.67)

1.36 (1.23–1.50)

 < 0.001

 60–80

4.86 (4.19–5.64)

2.13 (1.79–2.54)

 < 0.001

 ≥ 80

12.37 (8.36–18.67)

9.21 (5.79–14.66)

 < 0.001

 Absolute platelet count on day2 b

1.36 (1.33–1.38)

1.24 (1.21–1.27)

 < 0.001

Patient without coagulopathy related complications

Relative platelet reduction (%)

 < 20

Reference

Reference

 

 20–40

1.63 (1.75–1.68)

1.25 (1.21–1.3)

 < 0.001

 40–60

2.96 (2.8–3.12)

1.85 (1.74–1.97)

 < 0.001

 60–80

5.89 (5.32–6.53)

3.18 (2.82–3.59)

 < 0.001

 ≥ 80

12.26 (9.36–16.06)

6.13 (4.52–8.31)

 < 0.001

 Absolute platelet count on day2b

1.39 (1.37–1.4)

1.18 (1.17–1.2)

 < 0.001

  1. CI confidence interval; SOFA sequential organ failure assessment.
  2. aVariables in the model included patient age, sex, race, Charlson comorbidity index, relative platelet reduction, absolute platelet count on day 2, Acute Physiology and Chronic Health Evaluation (APACHE) IV score, focus of infection, body mass index, nosocomial onset, number of ICU visit, types of unit, region, teaching status, and hospital bed size. Hospital admission as a random intercept to account for clustering by hospital.
  3. bCategorized based on Hematology component of SOFA score.
  4. cDefined as platelet count ≤ 100 × 103/μL on day 2.
  5. dDefined as circulatory component of SOFA score ≥ 3.
  6. eDefined as respiratory component of SOFA score ≥ 3.
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