Figure 3 | Scientific Reports

Figure 3

From: Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol–conjugated heteroduplex oligonucleotide in mice

Figure 3The alternative text for this image may have been generated using AI.

Delivery of Toc-HDO-antimiR #7 in ischemic stroke. (a) Oligonucleotide concentrations in the ischemic brain region of the ipsilateral hemisphere (ipsi) and the non-ischemic brain tissue of the contralateral hemisphere (contra) in pMCAO model mice after injection of Cy3-labeled Toc-HDO-antimiR #7 or Cy3-labeled antimiR #7. Data are presented as the mean ± s.e.m (n = 3 per group). **P < 0.01 versus the ipsi in pMCAO model mice after injection of Cy3-labeled Toc-HDO-antimiR #7 (one-way ANOVA followed by Tukey–Kramer test) (b) Confocal laser scanning microscopic images of brain sections in the ischemic region after injection of Cy3-labeled Toc-HDO-antimiR #7 or Cy3-labeled antimiR #7 (red). Scale bar, 50 µm. (c) Immunofluorescence images of Cy3-labeled Toc-HDO-antimiR #7 (red) and antibody against endothelial cell marker (anti-CD31; green), and Hoechst staining (blue). Scale bar, 25 µm.

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