Figure 5 | Scientific Reports

Figure 5

From: Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol–conjugated heteroduplex oligonucleotide in mice

Figure 5The alternative text for this image may have been generated using AI.

Upregulation of miR-126 target genes by Toc-HDO-antimiR #7 in ischemic stroke. qRT-PCR analysis of the mRNA levels of the miR-126 downstream genes, Vcam1, Akt2, and Sgpl1 in the ischemic region of pMCAO model mice after two intravenous injections (at 1-week intervals) of Toc-HDO-antimiR #7 at 5 mg/kg or 50 mg/kg. Data are relative to Gapdh mRNA levels and are presented as the mean ± s.e.m. (n = 3 per group. *P < 0.05, **P < 0.01 versus PBS control). P values were calculated using one-way ANOVA followed by Dunnett’s test.

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