Figure 8 | Scientific Reports

Figure 8

From: Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states

Figure 8

Model of Notch inhibition effects on cone/HC regulatory network. Schematic of the general relationship between multipotent RPCs (mpRPC, beige), cone/HC RPCs (green), cones (blue), and HCs (purple). Grey shading denotes cell-type limits of Notch inhibition. CAG::MAML-DN is broadly active in all cells (denoted by grey shading) and leads to reduction in mpRPCs, increase in cone/HC RPCs and cones. Bottom graphs represent relative numbers of cell type populations under control and Notch inhibition conditions. Dotted lines represent decreased numbers.

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