Figure 5
From: Cell type-specific roles of PAR1 in Coxsackievirus B3 infection
Effect of PAR1 activation on poly I:C induction of CXCL10 expression in rat neonatal cardiac fibroblasts and cardiac myocytes. Rat neonatal cardiac fibroblasts (A) and cardiac myocytes (B) were stimulated with either poly I:C (25 µg/mL), PAR1 agonist peptide (TFLLR, 200 µM), thrombin (IIa, 5 nM) or combinations of agonists for 8 h. Levels of CXCL10 in the supernatant were measure by ELISA in triplicate. Data are mean ± SEM and analyzed by 1-way ANOVA with Bonferroni post-test. *P < 0.05 vs unstimulated control, #P < 0.01 vs poly I:C treated sample. (N = 3).
