Figure 6 | Scientific Reports

Figure 6

From: Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive

Figure 6

Carotid body ablation (CBA) in HF-EX-T rats induces a phenotypic switch from exercise tolerant to exercise intolerant. (A) Summary data showing training time before and after CBA in HF-EX-T rats. Note that CBA was associated with significantly lower training time in rats that were previously tolerant of EX. (B) Representative traces of HVR from one HF + EX-T rat before and 2 weeks post-CBA. (C) Summary data of minute ventilation during normoxia and hypoxia. Note that ventilatory response to hypoxia was significantly reduced after CBA. *p < 0.05 vs. HF + EX-T during hypoxia. HF + EX-T, n = 4; HF + EX-T + CBA, n = 4.

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