Table 1 Basic demographic and clinical characteristics of enrolled MM and EMM patients.

From: Whole-genome optical mapping of bone-marrow myeloma cells reveals association of extramedullary multiple myeloma with chromosome 1 abnormalities

Clinical features

All patients (n = 11)

EMM (n = 4)

MM (n = 7)

Male/female

8/3

3/1

5/2

Age (years), median (min–max)

77 (51–82)

77 (51–79)

75 (62–82)

ISS staging, n (%)

ISS I

5 (45.5)

2 (50.0)

3 (42.9)

ISS II

1 (9.1)

0 (0.0)

1 (14.3)

ISS III

5 (45.5)

2 (50.0)

3 (42.9)

Durie-Salmon stage, n (%)

IA

1 (9.1)

0 (0.0)

1 (14.3)

IIA

4 (36.4)

1 (25.0)

3 (42.9)

IIIA

4 (36.4)

2 (50.0)

2 (28.6)

IB

1 (9.1)

0 (0.0)

1 (14.3)

IIIB

1 (9.1)

1 (25.0)

0 (0.0)

LC + FLC, n (%)

IgG kappa

5 (45.5)

3 (75.0)

2 (28.6)

IgA kappa

4 (36.4)

0 (0.0)

4 (57.1)

IgA lambda

2 (18.2)

1 (25.0)

1 (14.3)

Cytogenetic analysisa, n (%)

t(4;14)

1 (9.1)

0 (0.0)

1 (14.3)

t(11;14)

1 (9.1)

0 (0.0)

1 (14.3)

Gain (1q21)

6 (54.5)

2 (50.0)

4 (57.1)

del(13q14)

4 (36.4)

1 (25.0)

3 (42.8)

del(1p32)

1 (9.1)

1 (25.0)

0 (0.0)

del(17p)

0 (0.0)

0 (0.0)

0 (0.0)

Monosomy

5 (45.5)

2 (50.0)

3 (42.8)

Trisomy

9 (81.8)

4 (100.0)

5 (71.4)

Tetrasomy

5 (45.5)

3 (75.0)

2 (28.6)

NGS analysisb, n (%)

TP53

0 (0.0)

0 (0.0)

0 (0.0)

KRAS

2 (18.2)

1 (25.0)

1 (14.3)

NRAS

0 (0.0)

0 (0.0)

0 (0.0)

BRAF

3 (27.3)

1 (25.0)

2 (28.6)

  1. ISS International Staging System, LC monoclonal protein's light chain, FLC free light chain.
  2. a10% positive cut-off level used.
  3. bThe full coding sequence of the TP53 gene (exons 2–11, plus 5′ and 3′UTR; NM_000546) and the hotspot regions in NRAS (exons 2–4; NM_002524), KRAS (exons 2–4; NM_004985) and BRAF (exons 11 and 15; NM_004333) were sequenced.
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