Table 2 Exposure margin against seizure after acute treatment in rats (plasma Cmax and AUCplasma).

From: Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement

 

TAK-653

TAK-137

LY451646

Margin based on plasma Cmax (fold)

419

42

3.4

Margin based on AUCplasma (fold)

1017

122

4.0

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