Table 3 Mean number of injections and proportion of eyes without a yearly injection.

From: Long-term outcomes of ranibizumab vs. aflibercept for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

Characteristics

Total eyes

Typical nAMD

PCV

Ranibizumab

Aflibercept

p value

Ranibizumab

Aflibercept

p value

Ranibizumab

Aflibercept

p value

Number of Injections, mean ± SD

1 year

4.12 ± 1.62

4.51 ± 1.53

0.080*

4.20 ± 1.81

4.51 ± 1.53

0.342*

4.05 ± 1.41

4.51 ± 1.55

0.119*

2 years

2.00 ± 1.87

1.84 ± 1.51

0.585*

2.00 ± 2.08

1.91 ± 1.60

0.843*

2.00 ± 1.69

1.76 ± 1.43

0.527*

3 years

1.64 ± 1.90

1.51 ± 1.65

0.726*

1.73 ± 2.12

1.32 ± 1.70

0.452*

1.56 ± 1.73

1.71 ± 1.62

0.734*

4 years

1.35 ± 1.64

1.64 ± 1.92

0.716*

1.56 ± 1.78

1.21 ± 2.02

0.544*

1.17 ± 1.51

1.78 ± 1.83

0.217*

Mean yearly injections, mean ± SD

2.92 ± 1.66

3.01 ± 1.46

0.692*

3.14 ± 1.98

3.01 ± 1.59

0.701*

2.70 ± 1.24

3.01 ± 1.33

0.222*

Proportion of eyes without a yearly injection, n (%)

2 years

28/85 (32.9%)

17/64 (26.6%)

0.401

15/40 (37.5%)

9/35 (25.7%)

0.275

13/45 (28.9%)

8/29 (27.6%)

0.903

3 years

32/66 (48.5%)

19/43 (44.2%)

0.660

15/30 (50.0%)

11/22 (50.0%)

1.000

17/36 (47.2%)

8/21 (38.1%)

0.503

4 years

29/57 (50.9%)

19/37 (51.4%)

0.964

13/27 (48.1%)

12/19 (63.2%)

0.314

16/30 (53.3%)

7/18 (38.9%)

0.332

  1. nAMD neovascular age-related macular degeneration, PCV polypoidal choroidal vasculopathy.
  2. *Independent t-test.
  3. Pearson chi-square test.