Table 1 Characteristics of all patients included in the present study.

From: Prognostic stratification for IDH-wild-type lower-grade astrocytoma by Sanger sequencing and copy-number alteration analysis with MLPA

 

Total

DA, IDH-wt

AA, IDH-wt

p-value*

All tumours

Number, n

42

18

24

 

Sex, men, n

31

13

18

1

Age (year), median (range)

55.5 (5–85)

56.5 (5–85)

55 (8–85)

0.964

cIMPACT-NOW update 3 "grade 4", n

21

9

12

1

TERTp mutation, n

18

9

9

0.533

EGFR amplification, n

8

1

7

0.109

EGFR gain and PTEN loss, n

6

3

3

1

PTEN loss, n

11

3

8

0.299

PDGFR amplification, n

4

0

4

0.122

CDKN2A homozygous loss, n

8

1

7

0.109

MGMTp hypermethylation, n

13

6

7

1

Patients for survival analysis

Number, n

40

18

22

 

Age (years), median (range)

57 (5–85)

56.5 (5–85)

59 (8–85)

0.725

Initial treatment

Chemoradiotherapy, n

28

9

19

0.0246

Chemotherapy, n

2

1

1

 

Observation, n

10

8

2

 
  1. AA anaplastic astrocytoma; DA diffuse astrocytoma; IDH-wt, IDH wild type.
  2. *The p-values for comparisons between DA and AA groups are calculated with Student's t-test for age and with Fisher's exact test for the others.