Figure 2

Patients who had a positive result for myelin oligodendrocyte glycoprotein antibodies presenting with brain lesion without diagnosis. (a, b) Images of a 12-year-old boy presenting with acute visual loss in the left eye for 10 days. One month ago, he experienced sudden loss of consciousness and a seizure. Fundoscopy (a) shows obvious edema of the optic disc, and brain and orbit magnetic resonance imaging (MRI) (b) shows enlarged and enhanced left optic nerve with brain lesions, indicating acute disseminated encephalomyelitis-like demyelinating disease, which was the probable cause for the seizure. (c, d) Images of a 30-year-old woman presenting with acute visual decrease in the right eye for 2 weeks. One month ago, she complained of weakness in her right body, while brain MRI showed a midbrain lesion, which recovered spontaneously. Fundoscopy (c) shows a severe swelling of the optic disc, and orbit MRI (d) shows extensive enhancement of the nerve.