Table 3 Prognostic factors for 1-, 3-, 5-year(s) DFS and OS by univariate analysis.
Indicators | n | DFS | P | OS | P | ||||
|---|---|---|---|---|---|---|---|---|---|
1-year | 3-years | 5-years | 1-year | 3-years | 5-years | ||||
Gender | |||||||||
Male | 727 | 66.4% | 43.1% | 31.3% | 0.179 | 87.5% | 64.1% | 48.8% | 0.405 |
Female | 141 | 65.2% | 49.4% | 39.7% | 82.3% | 64.6% | 56.5% | ||
Age (years) | |||||||||
< 60 | 645 | 63.7% | 43.2% | 31.9% | 0.086 | 85.3% | 63.1% | 49.7% | 0.381 |
≥ 60 | 214 | 74.8% | 47.8% | 35.9% | 91.1% | 68.0% | 52.2% | ||
BCLC | |||||||||
0-A | 745 | 69.1% | 47.7% | 35.8% | < 0.001** | 87.8% | 67.6% | 53.5% | < 0.001** |
B-D | 123 | 48.8% | 22.5% | 13.4% | 79.7% | 43.4% | 27.7% | ||
PLT (109/L) | |||||||||
< 100 | 268 | 71.6% | 50.5% | 36.0% | 0.023* | 91.0% | 73.2% | 58.7% | < 0.001** |
≥ 100 | 600 | 63.8% | 41.3% | 31.2% | 84.7% | 60.2% | 46.1% | ||
TLC (109/L) | |||||||||
< 1.1 | 191 | 64.8% | 44.5% | 32.9% | 0.947 | 86.9% | 60.5% | 48.1% | 0.809 |
≥ 1.1 | 677 | 66.6% | 44.0% | 32.6% | 86.6% | 65.3% | 50.5% | ||
WBC (109/L) | |||||||||
< 4.0 | 114 | 75.4% | 54.3% | 39.4% | 0.064 | 91.2% | 71.0% | 52.6% | 0.177 |
≥ 4.0 | 429 | 65.0% | 42.5% | 31.2% | 86.9% | 64.3% | 48.7% | ||
ALB (g/L) | |||||||||
< 40 | 297 | 66.7% | 42.8% | 30.5% | 0.655 | 85.2% | 61.7% | 46.0% | 0.059 |
≥ 40 | 571 | 66.0% | 44.8% | 34.0% | 87.4% | 65.5% | 52.2% | ||
TBil (μmol/L) | |||||||||
< 28 | 831 | 66.4% | 43.6% | 33.1% | 0.967 | 86.8% | 64.2% | 49.5% | 0.433 |
≥ 28 | 37 | 62.2% | 56.8% | 23.9% | 83.8% | 64.8% | 61.2% | ||
AST (IU/L) | |||||||||
< 40 | 456 | 71.7% | 50.6% | 38.3% | < 0.001** | 90.6% | 70.2% | 56.3% | < 0.001** |
≥ 40 | 412 | 60.1% | 37.0% | 26.6% | 82.3% | 57.6% | 43.1% | ||
ALT (IU/L) | |||||||||
< 50 | 565 | 66.3% | 45.1% | 33.9% | 0.303 | 86.9% | 66.0% | 50.6% | 0.253 |
≥ 50 | 303 | 66.0% | 42.3% | 30.5% | 86.1% | 60.8% | 48.7% | ||
HBV-DNA (cps/ml) | |||||||||
< 1000 | 315 | 69.8% | 50.9% | 40.9% | 0.001** | 89.8% | 69.6% | 57.8% | 0.001** |
≥ 1000 | 421 | 62.4% | 37.8% | 25.0% | 84.6% | 61.5% | 44.7% | ||
AFP (ng/ml) | |||||||||
< 400 | 526 | 75.7% | 52.2% | 37.9% | < 0.001** | 92.6% | 72.5% | 58.0% | < 0.001** |
≥ 400 | 340 | 51.7% | 31.5% | 24.3% | 77.4% | 51.1% | 37.4% | ||
max-D (cm) | |||||||||
< 5 | 387 | 78.8% | 58.3% | 42.3% | < 0.001** | 94.3% | 77.4% | 64.6% | < 0.001** |
≥ 5 | 476 | 56.5% | 32.9% | 24.8% | 80.9% | 53.7% | 38.7% | ||
Number | |||||||||
1 | 719 | 68.7% | 48.1% | 36.2% | < 0.001** | 87.5% | 67.2% | 53.4% | < 0.001** |
≥ 2 | 149 | 54.4% | 25.1% | 15.4% | 82.6% | 49.6% | 32.5% | ||
Ishak (score) | |||||||||
0–4 | 297 | 64.6% | 43.0% | 33.3% | 0.614 | 85.9% | 62.0% | 49.7% | 0.539 |
5–6 | 571 | 67.0% | 44.7% | 32.2% | 87.0% | 65.4% | 50.2% | ||
LCI | |||||||||
No | 254 | 72.3% | 47.5% | 34.8% | 0.012* | 90.2% | 70.4% | 51.8% | 0.003** |
Yes | 467 | 58.5% | 39.3% | 32.1% | 82.7% | 57.0% | 44.0% | ||
DD (grade) | |||||||||
1–2 | 501 | 73.1% | 49.9% | 36.0% | < 0.001** | 91.6% | 72.1% | 56.3% | < 0.001** |
3 | 367 | 56.9% | 36.1% | 28.1% | 79.8% | 53.3% | 41.4% | ||
MVI | |||||||||
No | 642 | 71.9% | 49.5% | 37.3% | < 0.001** | 89.4% | 69.4% | 55.6% | < 0.001** |
Yes | 226 | 50.0% | 29.0% | 19.4% | 78.8% | 49.4% | 33.9% | ||
SF | |||||||||
No | 754 | 69.1% | 47.7% | 35.7% | < 0.001** | 88.3% | 68.5% | 53.6% | < 0.001** |
Yes | 114 | 47.4% | 20.9% | 12.5% | 75.4% | 35.5% | 25.4% | ||
PNI | |||||||||
≤ 46 | 230 | 62.6% | 38.4% | 23.9% | 0.007** | 84.3% | 57.1% | 38.8% | < 0.001** |
> 46 | 638 | 67.5% | 46.2% | 35.8% | 87.5% | 66.8% | 54.2% | ||
ALBI | |||||||||
>− 2.8 | 421 | 63.6% | 40.9% | 27.6% | 0.013* | 83.4% | 58.4% | 44.4% | < 0.001** |
≤− 2.8 | 447 | 68.7% | 47.1% | 37.7% | 89.7% | 69.7% | 55.3% | ||
