Figure 4

Multivariate analysis from plasma metabolome profile of severe patients versus non-survivors. (a) Score scatter plot based on the PLS-DA models to explain the diagnosis (red for severe patients and black for non-survivors, (b) rank of the different metabolites (the top 15) identified by the PLS-DA according to the VIP coefficient on the x-axis. The color boxes indicate whether metabolite concentration is increased (red) or decreased (blue) in non-survivors vs severe patients (c) ROC curve of the metabolite-only model; (d) ROC curve of the metabolite + demographic/clinical data model. The figures were drawn via metaboanalyst software v 4.0 (https://www.metaboanalyst.ca/).