Table 1 Histological analysis of rat tail IVD-NPs.

From: A comparative study of mesenchymal stem cell transplantation and NTG-101 molecular therapy to treat degenerative disc disease

 

Morphology (M)

Cellularity (C)

Saf O intensity (I)

Total score = M + C + I

Average score (IVD-NP, n = 15)

Healthy, uninjured

1.1 ± 0.1

1.2 ± 0.2

1.6 ± 0.5

3.9 ± 0.5

PBS

2.6 ± 1.0

2.8 ± 0.9

2.2 ± 0.6

7.6 ± 2.0

NTG-101

1.1 ± 0.2

1.5 ± 0.5

1.6 ± 0.5

4.2 ± 1.0

rCDSCs

1.2 ± 0.2

2.2 ± 0.6

1.8 ± 0.3

5.2 ± 0.8

rBMSCs

2.1 ± 1.2

2.6 ± 1.0

2.0 ± 0.5

6.8 ± 2.5

hUCMSCs

2.2 ± 1.4

2.9 ± 1.0

1.8 ± 0.6

6.9 ± 2.0

p-value

PBS vs. Healthy

< 0.001

< 0.001

0.005

< 0.001

NTG-101 vs. PBS

< 0.001

< 0.001

0.007

< 0.001

rCDSCs vs. PBS

< 0.001

0.036

0.036

< 0.001

rBMSCs vs. PBS

0.267

0.635

0.387

0.315

hUCMSCs vs. PBS

0.365

0.778

0.081

0.315

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