Figure 6

(A) Latency to fall (s) from the rotarod in Sham and 6-OHDA-lesioned mice treated either with bulk L-DOPA, NANO-Control (NANO-CT; 10 or 20 mg/animal; NANO + Dopamine (NANO-DA; 10 or 20 mg/animal); dopamine-loaded-albumin/PLGA nanosystems (ALNP + DA; 10 or 20 mg/animal); and unloaded albumin/PLGA nanosystems (ALNP-CT; 10 and 20 mg/animal). Data were submitted to ANOVA multivariate analysis, followed by the Bonferroni post-test. Letters indicate statistically significant difference (p < 0.001). (a) Sham, (b) L-DOPA, (c) Lesioned, (d) NANO + DA 10 mg, (e) NANO + DA 20 mg, (f) NANO-CT 10 mg, (g) NANO-CT 20 mg, (h) ALNP + DA 10 mg, (i) ALNP + DA 20 mg, (j) ALNP-CT 10 mg, (k) ALNP-CT 20 mg. N = 7 animals/group. (B) Area under the curve (AUC) analysis for the latency to fall test in Sham and 6-OHDA-lesioned mice submitted to the mentioned treatments in A. Data were submitted to one-way ANOVA, followed by Tukey post-test. Significant differences: (***) p < 0.001 in relation to Lesioned group; (⁺) p < and (⁺⁺⁺) p < 0.001 in relation to Sham group; (^#) p < 0.05 and (^###) p < 0.001 in relation to L-DOPA group. N = 7 animals/group.