Figure 9 | Scientific Reports

Figure 9

From: Dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson’s Disease

Figure 9

(A) Data show percentage of remaining dopaminergic neurons reactive to tyrosine hydroxylase (TH+) on the 6-OHDA lesioned side, compared to the intact hemisphere (corresponds to 100%), according to experimental group. Data were submitted to one-way ANOVA analysis of variance, followed by the Tukey post-test. Graphs show mean ± SEM. (*) p < 0.05 and (***) p < 0.001 when compared to Sham. (B) Fluorescence micrographs of substantia nigra (SN) coronal sections stained for TH+ show the non-lesioned (contralateral) and 6-OHDA lesioned (ipsilateral) SN, inducing partial TH+ cell loss. Animals were treated with dopamine-loaded albumin/PLGA nanosystems (ALNP-DA) (20 mg/animal). Magnification: ×10. N = 7 animals/group.

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